Solute Carrier Family 14 (Urea Transporter, Kidney) Member 2 (SLC14A2) (AA 911-929) antibody (APC)

Catalog No. ABIN2486308

Product Details

Target: Solute Carrier Family 14 (Urea Transporter, Kidney) Member 2 (SLC14A2)

See all Solute Carrier Family 14 (Urea Transporter, Kidney) Member 2 (SLC14A2) Antibodies

Binding Specificity: AA 911-929

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: APC

Application: Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)

Specificity: Detects ~97 and 127 kDa.

Purification: Protein A Purified

Immunogen: Produced against a synthetic peptide mapped to the C-terminal tail (amino acids 911-929) of rat UT-A1 (antibody designation L194)

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:25)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN2486308 was sufficient for detection of UT-A1 in 20 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Target Details

Target: Solute Carrier Family 14 (Urea Transporter, Kidney) Member 2 (SLC14A2)

See all Solute Carrier Family 14 (Urea Transporter, Kidney) Member 2 (SLC14A2) Antibodies

Alternative Name: UT-A1 (SLC14A2 Antibody Abstract)

Synonyms: HUT2, UT-A2, UT2, UTA, UTR, hUT-A6, Slc14a2T, Slc14a2_v4, UrT1-C, UrT1-D, testSymbol, UT-A1, UT-A3, solute carrier family 14 member 2, solute carrier family 14 (urea transporter), member 2, SLC14A2, Slc14a2

Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2) (1, 2).

Gene ID: 54302

NCBI Accession: NP_062220

UniProt: Q62668

Pathways: Response to Water Deprivation