CHMP2A antibody (Charged Multivesicular Body Protein 2A) (AA 20-50) (Alexa Fluor 350)

Details for Product anti-CHMP2A Antibody No. ABIN2559688
Antigen
  • BC-2
  • BC2
  • CHMP2
  • VPS2
  • VPS2A
  • 1500016L11Rik
  • RGD1305050
  • bc-2
  • bc2
  • chmp2
  • vps2
  • vps2a
  • fj10d05
  • wu:fi18h03
  • wu:fj10d05
  • zgc:55361
  • charged multivesicular body protein 2a
  • charged multivesicular body protein 2A
  • Charged multivesicular body protein 2a
  • charged multivesicular body protein 2A L homeolog
  • ATEG_06167
  • LOC5570080
  • EDI_289610
  • PTRG_09933
  • NAEGRDRAFT_39042
  • PITG_17335
  • Tsp_00033
  • LOC100284170
  • LOC100284688
  • chm2a
  • chmp2a
  • CHMP2A
  • Chmp2a
  • chmp2a.L
Epitope
AA 20-50
14
7
3
2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
58
24
24
4
4
4
3
3
2
2
1
1
1
1
Host
Rabbit
55
3
Clonality
Polyclonal
Conjugate
This CHMP2A antibody is conjugated to Alexa Fluor 350
6
5
5
2
2
2
2
2
2
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
33
22
13
12
7
1
Options
Immunogen KLH conjugated synthetic peptide derived from human CHMP2A
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others CHMP2A products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CHMP2A (CHMP2A Antibody Abstract)
Background

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Synonyms: BC2, BC-2, VPS2, CHMP2, VPS2A, Charged multivesicular body protein 2a, Chromatin-modifying protein 2a, CHMP2a, Putative breast adenocarcinoma marker BC-2, Vacuolar protein sorting-associated protein 2-1, Vps2-1, hVps2-1

Gene ID 27243
UniProt O43633
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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