Ret Proto-Oncogene antibody (C-Term)

Catalog No. ABIN2777172

Product Details anti-Ret Proto-Oncogene Antibody

Target: Ret Proto-Oncogene (RET)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Pig, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ret Proto-Oncogene antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EMKLVHRDLA ARNILVAEGR KMKISDFGLS RDVYEEDSYV KRSQGRIPVK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 90%, Horse: 100%, Human: 100%, Mouse: 90%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against RET. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1114 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ret Proto-Oncogene

Target: Ret Proto-Oncogene (RET)

Alternative Name: RET (RET Products)

Background: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Alias Symbols: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Protein Interaction Partner: NOTCH2NL, UBC, CBLC, PDLIM7, HSP90AA1, GRB2, CBL, RET, MCRS1, IKBKG, DOK3, DOK5, DOK4, DOK6, SHC3, FRS2, DOK2, AKAP5, CBLB, GAB1, DOK1, NRTN, MAPK3, GRB10, GRB7, GFRA1, MAPK8, GDNF, PTK2, SHC1, MAPK14, SRC, MAPK1, PRKAR2A, PTPN11, PLCG1, PIK3R1, CRK, STAT
Protein Size: 1114

Molecular Weight: 123 kDa

Gene ID: 5979

NCBI Accession: NM_000323, NP_000314

UniProt: P07949

Pathways: RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation