PSMC5 antibody (C-Term)

Catalog No. ABIN2780449

Product Details anti-PSMC5 Antibody

Target: PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequence: AEVKGVCTEA GMYALRERRV HVTQEDFEMA VAKVMQKDSE KNMSIKKLWK

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PSMC5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSMC5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 406 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMC5

Target: PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))

Alternative Name: PSMC5 (PSMC5 Products)

Synonyms: mSUG1 antibody, S8 antibody, SUG-1 antibody, SUG1 antibody, TBP10 antibody, TRIP1 antibody, p45 antibody, p45/SUG antibody, wu:fa14g03 antibody, wu:fb23a11 antibody, zgc:92464 antibody, sug-1 antibody, sug1 antibody, tbp10 antibody, Sug1 antibody, PSMC5 antibody, xsug1 antibody, protease (prosome, macropain) 26S subunit, ATPase 5 antibody, proteasome 26S subunit, ATPase 5 antibody, proteasome 26S subunit, ATPase 5 L homeolog antibody, proteasome 26S subunit, ATPase 5 S homeolog antibody, Psmc5 antibody, PSMC5 antibody, psmc5 antibody, psmc5.L antibody, psmc5.S antibody

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.PSMC5 is one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.
Alias Symbols: S8, p45, SUG1, SUG-1, TBP10, TRIP1, p45/SUG
Protein Interaction Partner: HUWE1, KRT38, KRT40, PDCL, CIITA, FOS, THAP11, SUMO2, SUMO3, Gabbr2, PSMD14, UBE3C, UBC, PSMB4, RPS13, RPL29, PSMD12, PSMD11, PSMD8, PSMD3, PSMD1, PSMC6, DYNC1I2, ABCF1, KCMF1, UCHL5, KIAA0368, UBR4, ADRM1, MAP2, PARK2, FBXO6, RORA, PSMC4, BAG3, HIV2gp7,
Protein Size: 406

Molecular Weight: 46 kDa

Gene ID: 5705

NCBI Accession: NM_002805, NP_002796

UniProt: P62195

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway