ABCC8 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8) (N-Term)

Details for Product anti-ABCC8 Antibody No. ABIN2781496
Antigen
  • ABC36
  • HHF1
  • HI
  • HRINS
  • MRP8
  • PHHI
  • SUR
  • SUR1
  • SUR1delta2
  • TNDM2
  • D930031B21Rik
  • Sur
  • Sur1
  • ATP binding cassette subfamily C member 8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • ABCC8
  • Abcc8
Alternatives
anti-Human ABCC8 antibody for ELISA
Epitope
N-Term
61
37
4
4
2
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
101
86
74
60
3
2
2
1
1
1
1
1
Host
Rabbit
83
35
16
Clonality
Polyclonal
Conjugate
This ABCC8 antibody is un-conjugated
9
8
6
6
5
4
4
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
117
79
54
34
34
21
7
4
2
2
1
1
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ABCC8
Blocking Peptide Blocking peptide for this product available: ABIN972735
Sequence PLAFCGSENH SAAYRVDQGV LNNGCFVDAL NVVPHVFLLF ITFPILFIGW
Predicted Reactivity Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
Characteristics This is a rabbit polyclonal antibody against ABCC8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Plasmids, Primers & others Plasmids, Primers & others ABCC8 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name ABCC8 (ABCC8 Antibody Abstract)
Background ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2
Protein Interaction Partner: ENSA, KCNJ11, CRYBB1, KCNJ8, RAPGEF4,
Protein Size: 1581
Molecular Weight 177 kDa
Gene ID 6833
NCBI Accession NM_000352, NP_000343
UniProt Q09428
Pathways Negative Regulation of Hormone Secretion
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1581 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody (ABIN2781496) anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody (ABIN2781496) WB Suggested Anti-ABCC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Posi...
Product cited in: Němcová-Fürstová, Kopperová, Balušíková, Ehrlichová, Brynychová, Václavíková, Daniel, Souček, Kovář: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, 2016 (PubMed).

Background publications Babenko: "A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling." in: The Journal of biological chemistry, Vol. 283, Issue 14, pp. 8778-82, 2008 (PubMed).

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