ABCC3 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3) (Middle Region)

Details for Product anti-ABCC3 Antibody No. ABIN2781505
Target
Binding Specificity
Middle Region
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10
9
8
4
4
2
1
1
1
1
1
1
1
Reactivity
Dog, Guinea Pig, Horse, Human, Pig, Rat
72
18
17
1
1
Host
Rabbit
53
13
7
Clonality
Polyclonal
Conjugate
This ABCC3 antibody is un-conjugated
6
5
5
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
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34
30
24
13
11
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6
3
2
1
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human ABCC3
Blocking Peptide Blocking peptide for this product available: ABIN972733
Sequence KVHMKGSVAY VPQQAWIQNC TLQENVLFGK ALNPKRYQQT LEACALLADL
Predicted Reactivity Dog: 77%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Pig: 86%, Rat: 79%
Characteristics This is a rabbit polyclonal antibody against ABCC3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Target
Alternative Name ABCC3 (ABCC3 Antibody Abstract)
Background ABCC3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2
Protein Interaction Partner: UBC, MLH1,
Protein Size: 1527
Molecular Weight 168 kDa
Gene ID 8714
NCBI Accession NM_003786, NP_003777
UniProt O15438
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1527 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images
Image no. 1 for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) (Middle Region) antibody (ABIN2781505) WB Suggested Anti-ABCC3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Pos...
Product cited in: Jeong, Kim, Shin, Park, Oh, Kim, Moon, Choi, Jeong, Shin, Kim: "Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis." in: Toxicology and applied pharmacology, Vol. 288, Issue 2, pp. 213-22, 2015 (PubMed).