ITM2C antibody (Middle Region)

Catalog No. ABIN2781948

Product Details anti-ITM2C Antibody

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against ITM2C. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 267 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: ITM2C (ITM2C Products)

Background: ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.
Alias Symbols: BRI3, BRICD2C, E25, E25C, ITM3
Protein Interaction Partner: UBC, Dlg4, RYK, BACE1, RNF7, STT3A, MTNR1B, FURIN,
Protein Size: 267

Molecular Weight: 30 kDa

Gene ID: 81618

NCBI Accession: NM_030926, NP_112188

UniProt: Q9NQX7