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GZMA antibody (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3)) (C-Term) Primary Antibody

GZMA Reactivity: Human, Rat, Dog, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785887
$389.00
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100 μL
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  • Target
    GZMA
    Binding Specificity
    • 15
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 53
    • 26
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Dog, Guinea Pig
    Host
    • 39
    • 11
    • 9
    Rabbit
    Clonality
    • 48
    • 11
    Polyclonal
    Conjugate
    • 29
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GZMA antibody is un-conjugated
    Application
    • 26
    • 24
    • 15
    • 13
    • 13
    • 10
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Sequence
    LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP GVYILLSKKH
    Predicted Reactivity
    Dog: 82%, Guinea Pig: 90%, Human: 100%, Rat: 75%
    Characteristics
    This is a rabbit polyclonal antibody against GZMA. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human GZMA
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 262 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GZMA
    Alternative Name
    GZMA (GZMA Antibody Abstract)
    Synonyms
    gzmA, GZMA, AW494114, Ctla-3, Ctla3, Hf, SE1, TSP-1, TSP1, CTLA3, HFSP, granzyme A, Granzyme A, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3), gzmA, GZMA, graa, Gzma
    Background
    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
    Alias Symbols: CTLA3, HFSP
    Protein Interaction Partner: HSP90AA1, HSPA4, HMGB2, APEX1, XRCC5, XRCC6, HIST2H2BE, SET, LMNA, HNRNPK, HDC, HIST1H1A, GZMA, GOLGA2, ACTG1, Ndufs3, NCL, LMNB1,
    Protein Size: 262
    Molecular Weight
    26 kDa
    Gene ID
    3001
    NCBI Accession
    NM_006144, NP_006135
    UniProt
    P12544
    Pathways
    Apoptosis
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