GZMA antibody (AA 29-260)
Quick Overview for GZMA antibody (AA 29-260) (ABIN7177245)
Target
See all GZMA AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 29-260
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Purpose
- Gzma Antibody
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Cross-Reactivity
- Human
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Purification
- Protein G purified
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Purity
- >95 %
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Immunogen
- Recombinant Mouse Granzyme A protein (29-260AA)
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Isotype
- IgG
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anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) antibody
GZMA Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) (full length) antibodyGZMA Reactivity: Human IP, ICC, FACS Host: Mouse Monoclonal CB9 unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) (AA 29-262) antibodyGZMA Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) antibodyGZMA Reactivity: Human, Mouse, Rat WB, IHC, IF, IC Host: Rabbit Polyclonal unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) (AA 29-262) antibodyGZMA Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) (AA 101-200) antibodyGZMA Reactivity: Human, Mouse WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) (AA 41-141) antibodyGZMA Reactivity: Human ELISA Host: Mouse Monoclonal 4C6 unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) antibodyGZMA Reactivity: Human WB, IHC, IP, IHC (p), FACS Host: Mouse Monoclonal CB9 unconjugated
anti-Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) (AA 110-159) antibodyGZMA Reactivity: Human, Mouse, Rat, Dog, Monkey WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))
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Alternative Name
- Gzma
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Background
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Background: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after \\\'Lys-31\\\' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after \\\'Lys-189\\\', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity).
Aliases: Gzma antibody, Ctla-3 antibody, Ctla3 antibody, Mtsp-1 antibody, Granzyme A antibody, EC 3.4.21.78 antibody, Autocrine thymic lymphoma granzyme-like serine protease antibody, CTLA-3 antibody, Fragmentin-1 antibody, T cell-specific serine protease 1 antibody, TSP-1 antibody
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UniProt
- P11032
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Pathways
- Apoptosis
Target
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