GZMA antibody (AA 29-262)

Catalog No. ABIN7154414

Product Details anti-GZMA Antibody

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Binding Specificity: AA 29-262

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMA antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Granzyme A protein (29-262AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: GZMA (GZMA Products)

Synonyms: gzmA antibody, GZMA antibody, AW494114 antibody, Ctla-3 antibody, Ctla3 antibody, Hf antibody, SE1 antibody, TSP-1 antibody, TSP1 antibody, CTLA3 antibody, HFSP antibody, granzyme A antibody, Granzyme A antibody, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) antibody, gzmA antibody, GZMA antibody, graa antibody, Gzma antibody

Background:

Background: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after \\\'Lys-31\\\' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after \\\'Lys-189\\\', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Aliases: CTL tryptase antibody, CTLA3 antibody, Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody, Cytotoxic T lymphocyte associated serine esterase 3 antibody, Cytotoxic T lymphocyte proteinase 1 antibody, Cytotoxic T-lymphocyte proteinase 1 antibody, Fragmentin 1 antibody, Fragmentin-1 antibody, GRAA_HUMAN antibody, Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody, Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease) antibody, Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody, Granzyme A antibody, Granzyme A precursor antibody, Granzyme-1 antibody, GZMA antibody, H factor antibody, Hanukah factor serine protease antibody, Hanukkah factor antibody, HF antibody, HFSP antibody, TSP1 antibody

UniProt: P12544

Pathways: Apoptosis