TNFSF8 antibody (N-Term)

Catalog No. ABIN2789625

Product Details anti-TNFSF8 Antibody

Target: TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ATIMVLVVQR TDSIPNSPDN VPLKGGNCSE DLLCILKRAP FKKSWAYLQV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against TNFSF8. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 234 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNFSF8

Target: TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))

Alternative Name: TNFSF8 (TNFSF8 Products)

Synonyms: CD153 antibody, CD30LG antibody, Cd30l antibody, CD30L antibody, TNFRSF8 antibody, TNFSF8 antibody, tumor necrosis factor (ligand) superfamily, member 8 antibody, TNF superfamily member 8 antibody, tumor necrosis factor superfamily member 8 antibody, Tnfsf8 antibody, TNFSF8 antibody

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CD153, CD30L, CD30LG, MGC138144
Protein Interaction Partner: TNFRSF8, ANG,
Protein Size: 234

Molecular Weight: 26 kDa

Gene ID: 944

NCBI Accession: NM_001244, NP_001235

UniProt: P32971