TNFSF8 Products
(Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))
Categories
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Featured TNFSF8 Categories
TNFSF8 Antibodies
High quality antibodies with extensive validation data.
TNFSF8 ELISA Kits
Reliable ELISA kits for a wide range of species.
TNFSF8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TNFSF8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7431086
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN7186208
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7431083
Quantity
100 μL
Datasheet
Datasheet
Recommended TNFSF8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970949
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960263
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960264
Quantity
96 tests
Datasheet
Datasheet
Recommended TNFSF8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274156
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274138
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN6961111
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TNFSF8 products
: "Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30- Tumors." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 27, Issue 10, pp. 1825-1835, (2019) (PubMed).: "CD117⁺ CD3⁻ CD56⁻ OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues." in: European journal of immunology, Vol. 41, Issue 6, pp. 1563-72, (2011) (PubMed).
: "Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1." in: The EMBO journal, Vol. 26, Issue 13, pp. 3086-97, (2007) (PubMed).
: "CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes." in: The Journal of clinical investigation, Vol. 116, Issue 9, pp. 2366-77, (2006) (PubMed).
: "Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 375-80, (2000) (PubMed).
: "Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 2, pp. 786-94, (2000) (PubMed).
: "High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus." in: Blood, Vol. 91, Issue 9, pp. 3323-32, (1998) (PubMed).
: "CD30-mediated signaling promotes the development of human T helper type 2-like T cells." in: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1655-61, (1996) (PubMed).
: "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF." in: Cell, Vol. 73, Issue 7, pp. 1349-60, (1993) (PubMed).
Synonyms and alternative names related to TNFSF8
tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8), TNF superfamily member 8 (TNFSF8), tumor necrosis factor superfamily member 8 (TNFSF8), TNF superfamily member 8 (Tnfsf8), Cd30l, CD30L, CD30LG, CD153, TNFRSF8, TNFSF8Protein level used designations for TNFSF8
- CD30 ligand
- CD30-L
- tumor necrosis factor ligand superfamily member 8
- CD153 antigen
- CD30 antigen ligand
- tumor necrosis factor receptor superfamily, member 8
- tumor necrosis factor (ligand) superfamily, member 8
- tumor necrosis factor superfamily member 8
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