ZFAND5 antibody (AA 121-213) (AbBy Fluor® 594)

Catalog No. ABIN2807634

Product Details anti-ZFAND5 Antibody (AbBy Fluor® 594)

Target: ZFAND5 (Zinc Finger, AN1-Type Domain 5 (ZFAND5))

Binding Specificity: AA 121-213

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFAND5 antibody is conjugated to AbBy Fluor® 594

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZFAND5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ZFAND5

Target: ZFAND5 (Zinc Finger, AN1-Type Domain 5 (ZFAND5))

Alternative Name: ZFAND5 (ZFAND5 Products)

Background:

Synonyms: ZA20D2, ZNF216, ZFAND5A, AN1-type zinc finger protein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216, ZFAND5

Background: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Gene ID: 7763

UniProt: O76080

Pathways: Platelet-derived growth Factor Receptor Signaling