BMPR1B antibody

Catalog No. ABIN2855400

Product Details anti-BMPR1B Antibody

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Cow, Human, Mouse, Rat

Characteristics: Rabbit polyclonal antibody to BMPR1B (bone morphogenetic protein receptor, type IB)
BMPR1B antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human BMPR1B. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:10000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T , A431 , HeLa , HepG2 , human BMPR1B-transfected 293T cells , Neuro2A , C8D30 , NIH-3T3 , Rat2

Validation: Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-BMPR1B antibody (ABIN2855400)

Chung, Gao, Jegga, Das: "Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a." in: Molecular and cellular endocrinology, Vol. 400, pp. 48-60, (2015) (PubMed).

Target Details for BMPR1B

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Alternative Name: bone morphogenetic protein receptor type 1B (BMPR1B Products)

Background: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.

Cellular Localization: Membrane

Molecular Weight: 57 kDa

Gene ID: 658

UniProt: O00238