DLC1 antibody (AA 204-463)

Catalog No. ABIN3015711

Product Details anti-DLC1 Antibody

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Binding Specificity: AA 204-463

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLC1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DAPKVNAVDT LNVKDIAPEK QLLNSAVIAQ QRRKPDPPKD ENERSTCNVV QNEFLDTPCT NRGLPLLKTD FGSCLLQPPS CPNGMSAENG LEKSGFSQHQ NKSPPKVKAE DGMQCLQLKE TLATQEPTDN QVRLRKRKEI REDRDRARLD SMVLLIMKLD QLDQDIENAL STSSSPSGTP TNLRRHVPDL ESGSESGADT ISVNQTRVNL SSDTESTDLP SSTPVANSGT KPKTTAIQGI SEKEKAGKLT FWFCFLANLF

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 204-463 of human DLC1 (NP_079043.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DLC1

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Alternative Name: DLC1 (DLC1 Products)

Background: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.,DLC1,ARHGAP7,HP,STARD12,p122-RhoGAP,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Signal Transduction,G protein signaling,Signal Transduction,DLC1

Molecular Weight: 50 kDa/54 kDa/114 kDa/122 kDa/126 kDa/170 kDa

Gene ID: 10395

UniProt: Q96QB1

Pathways: Tube Formation, Positive Regulation of Endopeptidase Activity