DLC1 antibody (AA 61-110)

Catalog No. ABIN1534080

This Rabbit Polyclonal antibody specifically detects DLC1 in IHC, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DLC1 antibody (AA 61-110) (ABIN1534080)

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-DLC1 Antibody

Binding Specificity: AA 61-110

Purpose: DLC-1 Antibody

Specificity: DLC-1 Polyclonal Antibody detects endogenous levels of DLC-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human RHG07. AA range:61-110

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for DLC1

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Background:

Synonyms: DLC1, ARHGAP7, KIAA1723, STARD12, Rho GTPase-activating protein 7, Deleted in liver cancer 1 protein, DLC-1, HP protein, Rho-type GTPase-activating protein 7, START domain-containing protein 12, StARD12, StAR-related lipid transfer protein

Background: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010],

Gene Name: DLC1

Protein Name: Rho GTPase-activating protein 7

Molecular Weight: 122 kDa

Gene ID: 10395

OMIM: 604258

UniProt: Q96QB1

Pathways: Tube Formation, Positive Regulation of Endopeptidase Activity