HSP90AA1 antibody (AA 433-732)

Catalog No. ABIN3020962

Product Details anti-HSP90AA1 Antibody

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Binding Specificity: AA 433-732

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP90AA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: NYKKFYEQFS KNIKLGIHED SQNRKKLSEL LRYYTSASGD EMVSLKDYCT RMKENQKHIY YITGETKDQV ANSAFVERLR KHGLEVIYMI EPIDEYCVQQ LKEFEGKTLV SVTKEGLELP EDEEEKKKQE EKKTKFENLC KIMKDILEKK VEKVVVSNRL VTSPCCIVTS TYGWTANMER IMKAQALRDN STMGYMAAKK HLEINPDHSI IETLRQKAEA DKNDKSVKDL VILLYETALL SSGFSLEDPQ THANRIYRMI KLGLGIDEDD PTADDTSAAV TEEMPPLEGD DDTSRMEEVD

Cross-Reactivity: Human, Monkey, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 433-732 of human Hsp90alpha (NP_005339.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:20 - 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-HSP90AA1 antibody (ABIN3020962)

Liu, Liu, Wang, Yu, Miao, Liu, Wang, Du, Yang: "Heat shock protein 90α couples with the MAPK-signaling pathway to determine meiotic maturation of porcine oocytes." in: Journal of animal science, Vol. 96, Issue 8, pp. 3358-3369, (2018) (PubMed).

Ding, Chen, Zhang, Huang, Zang, Li, Li, Wong: "Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery." in: The Journal of biological chemistry, Vol. 291, Issue 38, pp. 20125-35, (2017) (PubMed).

Wang, Yu, Wang, Li, Li, Wang, Song, Chu, Li: "Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing." in: Biomaterials, Vol. 78, pp. 27-39, (2016) (PubMed).

Target Details for HSP90AA1

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Alternative Name: HSP90AA1 (HSP90AA1 Products)

Background: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.,HSP90AA1,EL52,HEL-S-65p,HSP86,HSP89A,HSP90A,HSP90N,HSPC1,HSPCA,HSPCAL1,HSPCAL4,HSPN,Hsp103,Hsp89,Hsp90,LAP-2,LAP2,Epigenetics & Nuclear Signaling,RNA Binding,Nuclear Receptor Signaling,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Cell Cycle,Cytoskeleton,Actins,Extracellular Matrix,MMPs,Endocrine & Metabolism,Mitochondrial metabolism,Immunology & Inflammation,HSP90AA1

Molecular Weight: 84 kDa/98 kDa

Gene ID: 3320

UniProt: P07900

Pathways: M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals