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PICK1 antibody (Protein Interacting With Protein Kinase C, alpha 1) Primary Antibody

PICK1 Reactivity: Human, Mouse, Rat IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3022063
$589.88
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  • Target
    PICK1
    Reactivity
    • 71
    • 48
    • 36
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 66
    • 16
    • 7
    • 1
    Rabbit
    Clonality
    • 68
    • 22
    Polyclonal
    Conjugate
    • 29
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PICK1 antibody is un-conjugated
    Application
    • 69
    • 43
    • 18
    • 15
    • 12
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide of human PICK1
    Isotype
    IgG
  • Application Notes
    Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C/-80 °C
  • Target
    PICK1
    Alternative Name
    PICK1 (PICK1 Antibody Abstract)
    Synonyms
    PICK, PRKCABP, Prkcabp, prkcabp, MGC131295, PICK1, DKFZp470L2127, protein interacting with PRKCA 1, protein interacting with C kinase 1, protein interacting with PRKCA 1 L homeolog, PICK1, Pick1, pick1, pick1.L
    Background
    Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKC alpha activation. PKC alpha, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKC alpha. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.
    Synonyms: MGC15204, PICK, PRKCABP
    Gene ID
    9463
    UniProt
    Q9NRD5
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