Angiopoietin 2 antibody (ANGPT2) (AA 454-468)

Details for Product anti-ANGPT2 Antibody No. ABIN3043679
Antigen
  • AGPT2
  • ANG2
  • Agpt2
  • Ang-2
  • Ang2
  • ang2
  • angpt2
  • ANGIOPOIETIN-2
  • ANG-2
  • ANGPT2
  • angiopoietin 2
  • angiopoietin 2b
  • ANGPT2
  • Angpt2
  • angpt2b
Alternatives
anti-Human Angiopoietin 2 antibody for Western Blotting
Epitope
AA 454-468, C-Term
18
15
7
6
5
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
123
81
59
21
5
4
3
3
2
1
1
1
1
Host
Rabbit
138
15
6
2
1
1
Clonality
Polyclonal
Conjugate
This Angiopoietin 2 antibody is un-conjugated
15
7
6
4
4
4
4
4
4
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
103
63
60
20
17
15
13
10
8
7
6
2
2
Options
Purpose Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with WB in Human.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Angiopoietin 2(454-468aa NLNGMYYPQRQNTNK).
Sequence NLNGMYYPQR QNTNK
Isotype IgG
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with WB in Human.
Gene Name: angiopoietin 2
Protein Name: Angiopoietin-2(ANG-2)
Purification Immunogen affinity purified.
Plasmids, Primers & others Plasmids, Primers & others Angiopoietin 2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name ANGPT2 (ANGPT2 Antibody Abstract)
Background Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60 % homologous with Angiopoietin 1. Angiopoietin-2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. Angiopoietin 1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

Synonyms: AGPT 2 antibody|Agpt2 antibody|ANG 2 antibody|ANG-2 antibody|ANG2 antibody|Angiopoietin 2a antibody|Angiopoietin 2B antibody|Angiopoietin-2 antibody|Angiopoietin2 antibody|ANGP2_HUMAN antibody|ANGPT 2 antibody|ANGPT2 antibody|ANGPT-2 antibody|Tie2 ligand antibody
UniProt O15123
Pathways RTK Signaling
Application Notes WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Thimerosal (Merthiolate), Sodium azide
Precaution of Use This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Supplier Images
Western Blotting (WB) image for anti-Angiopoietin 2 (ANGPT2) (AA 454-468), (C-Term) antibody (ABIN3043679) Anti-Angiopoietin 2 antibody, Western blotting Lane 1: Recombinant Human ANG2 Protein...
Western Blotting (WB) image for anti-Angiopoietin 2 (ANGPT2) (AA 454-468), (C-Term) antibody (ABIN3043679) Anti-Angiopoietin 2 antibody, Western blotting Lane 1: Recombinant Human ANG2 Protein...
Product cited in: Huang, Pan, Yu, Guo, Wang, Zhang, Wang, Gao: "Benefical therapeutic effect of Chinese Herbal Xinji'erkang formula on hypertension-induced renal injury in the 2-kidney-1-clip hypertensive rats." in: African journal of traditional, complementary, and alternative medicines : AJTCAM, Vol. 11, Issue 5, pp. 16-27, 2015 (PubMed).

Bai, Li, Tian, Zhou: "Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes." in: PLoS ONE, Vol. 9, Issue 4, pp. e96117, 2014 (PubMed).

Li, Fan, Song, Zhang, Chen, Li, Mi, Ma, Song, Tao, Li: "Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma." in: PLoS ONE, Vol. 8, Issue 9, pp. e75388, 2013 (PubMed).

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