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Serotonin Receptor 2B antibody (HTR2B) Primary Antibody

HTR2B Reactivity: Human IF, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN317623
$513.70
Plus shipping costs $45.00
0.1 mg
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Available
  • Target
    Serotonin Receptor 2B (HTR2B)
    Reactivity
    • 57
    • 18
    • 17
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 54
    • 3
    Rabbit
    Clonality
    • 55
    • 2
    Polyclonal
    Conjugate
    • 30
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Serotonin Receptor 2B antibody is un-conjugated
    Application
    • 24
    • 22
    • 16
    • 13
    • 13
    • 9
    • 9
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    This antibody detects endogenous levels of SR-2B protein. (region surrounding His55)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen
  • Application Notes
    ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Serotonin Receptor 2B (HTR2B)
    Abstract
    HTR2B Antibody Abstract
    Synonyms
    5-HT2B, 5HT2B, 5htr2b, HTR2B, 5ht2b, zgc:194094, zgc:194119, AJ012488, AV377389, 5-HT(2B), 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 2B, HTR2B, htr2b, Htr2b
    Background
    Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.Synonyms: 5-HT-2B, 5-HT2B, 5-hydroxytryptamine receptor 2B
    Molecular Weight
    approx. 54 kDa
    Gene ID
    3357
    NCBI Accession
    NP_000858
    UniProt
    P41595
    Pathways
    JAK-STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process
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