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Integrin beta 3 antibody (ITGB3) (pTyr773) Primary Antibody

ITGB3 Reactivity: Human, Mouse IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN361990
$306.90
Plus shipping costs $45.00
100 μL ABIN361990
100 μL ABIN361990
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  • Target
    Integrin beta 3 (ITGB3)
    Binding Specificity
    • 22
    • 22
    • 16
    • 13
    • 9
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr773
    Reactivity
    • 214
    • 90
    • 61
    • 15
    • 15
    • 14
    • 14
    • 11
    • 9
    • 9
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 122
    • 96
    • 16
    • 2
    • 1
    Rabbit
    Clonality
    • 118
    • 117
    Polyclonal
    Conjugate
    • 113
    • 23
    • 14
    • 13
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Integrin beta 3 antibody is un-conjugated
    Application
    • 119
    • 111
    • 53
    • 52
    • 45
    • 39
    • 31
    • 27
    • 25
    • 16
    • 15
    • 11
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    The antibody detects endogenous level of Integrin b3 only when phosphorylated at tyrosine 773.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pTyr773 (P-L-Y (p) -K-E) derived from Human Integrin b3. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
  • Application Notes
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    Integrin beta 3 (ITGB3)
    Alternative Name
    Integrin beta3 (ITGB3 Antibody Abstract)
    Synonyms
    BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, INGRB3, integrin, INTB3, GPIIIA, cd61, gp3a, itgb3, itgb3.2, integrin subunit beta 3, integrin beta 3, integrin subunit beta 3 L homeolog, integrin beta 3a, ITGB3, Itgb3, itgb3.L, itgb3a
    Background
    Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    Molecular Weight
    110 kDa
    NCBI Accession
    NP_000203
    UniProt
    P05106
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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