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HSD11B2 antibody (Hydroxysteroid (11-Beta) Dehydrogenase 2) (AA 25-40) Primary Antibody

HSD11B2 Reactivity: Human, Mouse, Rat IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372479
$580.80
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Available
  • Target
    HSD11B2
    Binding Specificity
    • 18
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 25-40
    Reactivity
    • 48
    • 34
    • 34
    • 16
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 66
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 70
    Polyclonal
    Conjugate
    • 26
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This HSD11B2 antibody is un-conjugated
    Application
    • 42
    • 27
    • 26
    • 19
    • 16
    • 16
    • 10
    • 4
    • 4
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Sequence
    R25SDLRLGRPLL AALAL4
    Specificity
    This antibody recognizes 11-HSD2.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide corresponding to amino acids 25-40 of human 11 beta-HSD2.
    Isotype
    IgG
  • Application Notes
    Western blot: 1/200. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    TBS, pH 7.4 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA, 50 % Glycerol as stabilizers.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    HSD11B2
    Alternative Name
    11-beta HSD2 / HSD11B2 (HSD11B2 Antibody Abstract)
    Synonyms
    MGC81883, 11-HSD2, AME, AME1, HSD11K, HSD2, SDR9C3, 11HSD2, HSD11B2, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog, hydroxysteroid 11-beta dehydrogenase 2, hsd11b2.L, HSD11B2, Hsd11b2
    Background
    HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    Gene ID
    3291
    NCBI Accession
    NP_000187
    UniProt
    P80365
    Pathways
    Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
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