HSD11B2 antibody (Hydroxysteroid (11-Beta) Dehydrogenase 2) (AA 25-40) Primary Antibody
- AA 25-40
- Human, Mouse, Rat
- This HSD11B2 antibody is un-conjugated
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- R25SDLRLGRPLL AALAL4
- This antibody recognizes 11-HSD2.
- Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
- Immunoaffinity Chromatography.
- Synthetic peptide corresponding to amino acids 25-40 of human 11 beta-HSD2.
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 151-250) antibody Primary Antibody
HSD11B2 Reactivity: Mouse, Rat, Horse ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB Host: Rabbit Polyclonal unconjugatedanti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (N-Term) antibody Primary Antibody
HSD11B2 Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Sheep WB Host: Rabbit Polyclonal unconjugated
- Application Notes
Western blot: 1/200. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
- For Research Use only
- 1.0 mg/mL
- TBS, pH 7.4 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA, 50 % Glycerol as stabilizers.
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
- Alternative Name
- 11-beta HSD2 / HSD11B2 (HSD11B2 Antibody Abstract)
- MGC81883, 11-HSD2, AME, AME1, HSD11K, HSD2, SDR9C3, 11HSD2, HSD11B2, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog, hydroxysteroid 11-beta dehydrogenase 2, hsd11b2.L, HSD11B2, Hsd11b2
- HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
- Gene ID
- NCBI Accession
- Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones