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EGFR antibody

Name: EGFR antibody
SKU: ABIN372504
Price: 859.2 USD
Availability: InStock

EGFR Reactivity: Human, Mouse, Rat, Chicken WB, IF, IHC (p), IP, EIA Host: Sheep Polyclonal unconjugated

Image no. 1 for anti-Epidermal Growth Factor Receptor (EGFR) antibody (ABIN372504) (EGFR antibody)

1 image

Catalog No. ABIN372504

Datasheet as PDF

Target See all EGFR Antibodies

EGFR (Epidermal Growth Factor Receptor (EGFR))
Reactivity
749

295

282

25

25

23

19

14

8

3

2

2

1

1

1

1

1

1
Human, Mouse, Rat, Chicken
Host
580

167

14

13

4

4

1

1
Sheep
Clonality
541

238

2
Polyclonal
Conjugate
411

58

29

22

19

17

16

16

16

16

16

11

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

1

1

1

1

1

1
This EGFR antibody is un-conjugated
Application
534

250

149

147

125

102

97

92

82

46

37

34

33

18

11

8

6

5

4

4

3

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificity

This antibody recognizes Human Epidermal Growth Factor Receptor.

Cross-Reactivity (Details)

Species reactivity (expected):Chicken, Mouse and Rat.
Species reactivity (tested):Human.

Purification

Protein G Chromatography.

Immunogen

Recombinant 20 amino acid residues representing a portion of the internal domain of EGFR proximal to the phosphorylation region.

Isotype

IgG

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Application Notes

ELISA. Western Blot. Immunoprecipitation. Immunocytochemistry. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions

For Research Use only
Concentration

1.0 mg/mL

Buffer

0.15 M PBS, pH 7.2 without preservatives

Preservative

Without preservative

Handling Advice

Avoid repeated freezing and thawing.

Storage

4 °C/-20 °C

Storage Comment

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Alternative Name

EGFR / ERBB1 (EGFR Products)

Background

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.Synonyms: EGF Receptor, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, c-ErbB-1, erbB-1

Gene ID

1956

NCBI Accession

NP_005219

UniProt

P00533

Pathways

NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins