SLC29A1 antibody (C-Term)

Catalog No. ABIN387940

Product Details anti-SLC29A1 Antibody

Target: SLC29A1 (Solute Carrier Family 29 (Nucleoside Transporters), Member 1 (SLC29A1))

Binding Specificity: AA 402-431, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC29A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-431 amino acids from the C-terminal region of human ENT1.

Clone: RB09157

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:500. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-SLC29A1 antibody (ABIN387940)

Grenz, Bauerle, Dalton, Ridyard, Badulak, Tak, McNamee, Clambey, Moldovan, Reyes, Klawitter, Ambler, Magee, Christians, Brodsky, Ravid, Choi, Wen, Lukashev, Blackburn, Osswald, Coe, Nürnberg, Haase et al.: "Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. ..." in: The Journal of clinical investigation, Vol. 122, Issue 2, pp. 693-710, (2012) (PubMed).

Ibarra, Jain, Pfeiffer: "Host-based ribavirin resistance influences hepatitis C virus replication and treatment response." in: Journal of virology, Vol. 85, Issue 14, pp. 7273-83, (2011) (PubMed).

Ibarra, Pfeiffer: "Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance." in: Journal of virology, Vol. 83, Issue 9, pp. 4538-47, (2009) (PubMed).

Target Details for SLC29A1

Target: SLC29A1 (Solute Carrier Family 29 (Nucleoside Transporters), Member 1 (SLC29A1))

Alternative Name: ENT1 (SLC29A1 Products)

Background: ENT1 is a member of the equilibrative nucleoside transporter family. It is a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies.

Molecular Weight: 50219

Gene ID: 2030

NCBI Accession: NP_001071642, NP_001071643, NP_001071644, NP_001071645, NP_004946

UniProt: Q99808

Pathways: Carbohydrate Homeostasis, Synaptic Membrane