ACVR2B antibody (AA 1-30)

Catalog No. ABIN391162

Product Details anti-ACVR2B Antibody

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Binding Specificity: AA 1-30

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR2B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected between aa 1 and 30 of human ACVR2B.

Clone: RB08166

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ACVR2B antibody (ABIN391162)

McKay, Ogborn, Bellamy, Tarnopolsky, Parise: "Myostatin is associated with age-related human muscle stem cell dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 6, pp. 2509-21, (2012) (PubMed).

Target Details for ACVR2B

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Alternative Name: ACVR2B (ACVR2B Products)

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Molecular Weight: 57724

Gene ID: 93

NCBI Accession: NP_001097

UniProt: Q13705

Pathways: Hormone Transport, Cancer Immune Checkpoints