CD59 antibody

Catalog No. ABIN400702

This Mouse Monoclonal antibody specifically detects CD59 in FACS and IHC (p). It exhibits reactivity toward Human, Monkey, Baboon and Chimpanzee.

Quick Overview for CD59 antibody (ABIN400702)

Target: CD59

Reactivity: Human, Monkey, Baboon, Chimpanzee

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD59 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: P282 (H19)

Product Details anti-CD59 Antibody

Specificity: Recognizes CD59 Glycoprotein.

Cross-Reactivity (Details): Species reactivity (expected):Baboon, Chimpanzee and Monkey.
Species reactivity (tested):Human.

Characteristics: Synonyms: MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21,MACIF, MAC-IP, MIRL, HRF20, HRF-20, Membrane attack complex inhibition factor,Membrane inhibitor of reactive lysis, 20 kDa homologous restriction factor

Purification: Affinity Chromatography.

Immunogen: Full length protein corresponding to Human CD59.

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: 2 μg/IE6 cells. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background: CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin

Gene ID: 966

UniProt: P13987

Pathways: Complement System