Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody

Details for Product No. ABIN4904757
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
46
28
27
4
4
4
4
4
3
2
2
2
1
Host
Rabbit
43
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
30
14
13
10
6
3
2
2
1
1
1
Options
Immunogen Recombinant protein of human PICALM.
Isotype IgG
Characteristics This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Affinity purification
Antigen
Alternative Name PICALM (PICALM Antibody Abstract)
Gene ID 8301
UniProt Q13492
Pathways Synaptic Membrane
Application Notes WB 1:1000-1:2000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze/thaw cycles.
Storage -20 °C
Storage Comment Store at -20°C.
Supplier Images
Image no. 1 for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (ABIN4904757) Western blot analysis of extracts of various cells, using PICALM antibody.
Image no. 2 for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (ABIN4904757) Western blot analysis of extracts of various cell lines, using PICALM antibody (ABIN4...