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TGFBR1 antibody (AA 310-360) (PE)

TGFBR1 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal PE
Catalog No. ABIN4914599
  • Target See all TGFBR1 Antibodies
    TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
    Binding Specificity
    • 9
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 310-360
    Reactivity
    • 57
    • 43
    • 23
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 62
    • 4
    • 2
    • 2
    Rabbit
    Clonality
    • 65
    • 5
    Polyclonal
    Conjugate
    • 46
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TGFBR1 antibody is conjugated to PE
    Application
    • 51
    • 42
    • 24
    • 11
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Cow, Human, Mouse, Rat
    Predicted Reactivity
    Cow
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TGF-beta R1
    Isotype
    IgG
    Top Product
    Discover our top product TGFBR1 Primary Antibody
  • Application Notes
    FCM(1:20-100)
    Restrictions
    For Research Use only
  • Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
    Alternative Name
    TGF beta Receptor I (TGFBR1 Products)
    Background

    Synonyms: AAT5, ALK5, ESS1, LDS1, MSSE, SKR4, ALK-5, LDS1A, LDS2A, TGFR-1, ACVRLK4, TGF-beta receptor type-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGFBR1

    Background: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

    Gene ID
    7046
    UniProt
    P36897
    Pathways
    Growth Factor Binding
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