TGFBR1 antibody (AA 134-163)

Catalog No. ABIN392279

There are 4+ publications for this product available. The Rabbit Polyclonal anti-TGFBR1 antibody is suitable to detect TGFBR1 in samples from Human. It has been validated for WB and IHC.

Quick Overview for TGFBR1 antibody (AA 134-163) (ABIN392279)

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RB03530

Product Details anti-TGFBR1 Antibody

Binding Specificity: AA 134-163

Predicted Reactivity: B, M, Pig, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TGF Beta Receptor I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human TGF Beta Receptor I.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-TGFBR1 antibody (ABIN392279)

Yi, Li, Nie, Jia, Zhang, Wang, Wang: "Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice." in: BMC complementary and alternative medicine, Vol. 16, pp. 222, (2017) (PubMed).

Zhang, Chang, Li, Gao, Wang, Ma, Li, Wang: "miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling." in: Scientific reports, Vol. 5, pp. 18118, (2016) (PubMed).

Hou, Wu, Wei, Ren, Du, Wu, Li, Shi: "CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells." in: Biochemical and biophysical research communications, Vol. 468, Issue 1-2, pp. 281-6, (2015) (PubMed).

Miles, Tung, Aguiar, Kurtoglu, Sikes: "Increased TGF-?1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling." in: The Prostate, Vol. 72, Issue 12, pp. 1339-50, (2012) (PubMed).

Target Details for TGFBR1

Target: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Alternative Name: TGF beta Receptor I (TGFBR1)

Background: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

Molecular Weight: 55960

Gene ID: 7046

NCBI Accession: NP_001124388, NP_004603

UniProt: P36897

Pathways: Growth Factor Binding