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PTPN1 antibody

PTPN1 Reactivity: Human, Mouse ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032393
$578.58
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  • Target See all PTPN1 Antibodies
    PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
    Reactivity
    • 106
    • 79
    • 50
    • 16
    • 12
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 108
    • 11
    • 2
    • 2
    • 1
    Rabbit
    Clonality
    • 106
    • 18
    Polyclonal
    Conjugate
    • 63
    • 8
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTPN1 antibody is un-conjugated
    Application
    • 81
    • 48
    • 26
    • 25
    • 15
    • 13
    • 11
    • 11
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Purification
    Purified
    Immunogen
    This PTP1B antibody was produced from rabbits immunized with a recombinant protein encoding aa 1~321 of human PTP1B.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the PTP1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the PTP1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
    Alternative Name
    PTP1B (PTPN1 Products)
    Synonyms
    PTPN1 antibody, PTP1B antibody, PTP-1B antibody, PTP-HA2 antibody, Ptp antibody, ptp1b antibody, wu:fk54h03 antibody, CPTP1 antibody, protein tyrosine phosphatase, non-receptor type 1 antibody, protein tyrosine phosphatase, non-receptor type 1 L homeolog antibody, PTPN1 antibody, Ptpn1 antibody, ptpn1 antibody, ptpn1.L antibody
    Background
    PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
    UniProt
    P18031
    Pathways
    TLR Signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
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