OTUD5 antibody (AA 300-520)

Catalog No. ABIN5027170

Product Details anti-OTUD5 Antibody

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Binding Specificity: AA 300-520

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD5 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for OTUD5

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Alternative Name: DUBA (OTUD5 Products)

Background: DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.

Molecular Weight: 62 kDa

Gene ID: 55593

UniProt: Q96G74