TFG antibody (AA 196-400)

Catalog No. ABIN5027601

Product Details anti-TFG Antibody

Target: TFG (Trk-Fused Gene (TFG))

Binding Specificity: AA 196-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant TRK Fused gene protein (amino acids 196-400) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB:1-2 μg/mL, IHC: 20 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for TFG

Target: TFG (Trk-Fused Gene (TFG))

Alternative Name: TRK Fused gene (TFG Products)

Background: TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation.

Molecular Weight: 50 kDa

Gene ID: 10342

UniProt: Q92734