TCF7L2 antibody (AA 1-455)

Catalog No. ABIN520776

Product Details anti-TCF7L2 Antibody

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Binding Specificity: AA 1-455

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TCF7L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a full length recombinant TCF7L2.

Sequence: MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS LSPTARTYLQ MKWPLLDVQA GSLQSRQALK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWQGQP VYPITTGGFR HPYPTALTVN ASMSRFPPHM VPPHHTLHTT GIPHPAIVTP TVKQESSQSD VGSLHSSKHQ DSKKEEEKKK PHIKKPPNAF MLYMKEMRAK VVAECTLKES AAINQILGRR WHALSREEQA KYYELARKER QLHMQLYPGW SARDNYGKKK KRKRDKQPGE TNEHSECFLN PCLSLPPITG EKKSAFATYK VKAAASAHPL QMEAY

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: TCF7L2 (AAH32656, 1 a.a. ~ 455 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1A9

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-TCF7L2 antibody (ABIN520776)

da Silva Xavier, Loder, McDonald, Tarasov, Carzaniga, Kronenberger, Barg, Rutter: "TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells." in: Diabetes, Vol. 58, Issue 4, pp. 894-905, (2009) (PubMed).

Fancy, Baranzini, Zhao, Yuk, Irvine, Kaing, Sanai, Franklin, Rowitch: "Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS." in: Genes & development, Vol. 23, Issue 13, pp. 1571-85, (2009) (PubMed).

Target Details for TCF7L2

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Alternative Name: TCF7L2 (TCF7L2 Products)

Background: Full Gene Name: transcription factor 7-like 2 (T-cell specific, HMG-box)
Synonyms: TCF-4,TCF4

Gene ID: 6934

Pathways: WNT Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus