Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3879-3908), (C-Term) antibody

Details for Product No. ABIN5536269
Antigen
Epitope
AA 3879-3908, C-Term
9
9
7
7
4
2
2
2
1
1
1
1
1
Reactivity
Human
57
17
11
Host
Rabbit
44
13
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
34
31
28
10
4
3
3
3
2
2
1
Options
Immunogen This HRX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3879-3908 amino acids from the C-terminal region of human HRX.
Isotype Ig Fraction
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Antigen
Alternative Name HRX (MLL Antibody Abstract)
Background The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1,11)(q21,q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
Molecular Weight 432 kDa
Gene ID 4297
UniProt Q03164
Application Notes For FACS starting dilution is: 1:10~50

For IHC-P starting dilution is: 1:50~100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Supplier Images
Image no. 1 for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3879-3908), (C-Term) antibody (ABIN5536269) Flow cytometric analysis of CEM cells (right histogram) compared to a negative contro...
Image no. 2 for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3879-3908), (C-Term) antibody (ABIN5536269) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...