Integrin alpha 2 (ITGA2) (AA 574-712) antibody

Catalog No. ABIN5684082

Product Details

Target: Integrin alpha 2 (ITGA2)

See all Integrin alpha 2 (ITGA2) Antibodies

Binding Specificity: AA 574-712

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Flow Cytometry (FACS), Western Blotting (WB)

Immunogen: Purified recombinant fragment of human TBC1D4 (AA 574-712) expressed in E. Coli.

Clone: 8A11A2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.05 % sodium azide

Storage: 4 °C,-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details

Target: Integrin alpha 2 (ITGA2)

See all Integrin alpha 2 (ITGA2) Antibodies

Alternative Name: CD49B (ITGA2 Antibody Abstract)

Synonyms: BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, DX5, integrin subunit alpha 2, integrin alpha 2, ITGA2, Itga2

Background: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 146.5 kDa

HGNC: 9882

Pathways: CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex