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Integrin alpha 2 (ITGA2) (AA 574-712) antibody Primary Antibody

ITGA2 Reactivity: Human ELISA, FACS, WB Host: Mouse Monoclonal 8A11A2 unconjugated
Catalog No. ABIN5684082
$448.80
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0.1 mg
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  • Target
    Integrin alpha 2 (ITGA2)
    Binding Specificity
    AA 574-712
    Reactivity
    Human
    Host
    Mouse
    Clonality
    Monoclonal
    Conjugate
    Un-conjugated
    Application
    ELISA, Flow Cytometry (FACS), Western Blotting (WB)
    Immunogen
    Purified recombinant fragment of human TBC1D4 (AA 574-712) expressed in E. Coli.
    Clone
    8A11A2
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.05 % sodium azide
    Storage
    4 °C,-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    Integrin alpha 2 (ITGA2)
    Alternative Name
    CD49B (ITGA2 Antibody Abstract)
    Synonyms
    BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, DX5, integrin subunit alpha 2, integrin alpha 2, ITGA2, Itga2
    Background
    This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Molecular Weight
    146.5 kDa
    HGNC
    9882
    Pathways
    CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex
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