CISD2 antibody (CDGSH Iron Sulfur Domain 2) (AA 40-90) Primary Antibody
CISD2
Reactivity: Human, Mouse, Rat
ELISA, IF, IHC (p), WB
Host: Rabbit
Polyclonal
Catalog No. ABIN5689926
$380.00
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0.1 mg ABIN5689926
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- Target
- Binding Specificity
- AA 40-90
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- This CISD2 antibody is un-conjugated
- Application
- ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- Purification
- CISD2 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.
The immunogen is located within amino acids 40 - 90 of CISD2. - Isotype
- IgG
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- Application Notes
- CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- CISD2 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Target
- Alternative Name
- CISD2 (CISD2 Antibody Abstract)
- Background
- CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
- Molecular Weight
- Predicted: 15 kDa
Observed: 15 kDa - Gene ID
- 493856
- NCBI Accession
- NP_001008389
- UniProt
- Q8N5K1
- Pathways
- Activation of Innate immune Response
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