Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3), Member 3 Regulator 1 (SLC9A3R1) antibody

Details for Product No. ABIN5968198
Target
Reactivity
Human, Mouse, Rat
69
33
28
3
3
3
2
1
1
1
1
1
Host
Rabbit
59
9
1
Clonality
Polyclonal
Conjugate
Un-conjugated
5
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
52
25
17
13
13
13
8
4
1
1
1
1
Options
Immunogen Recombinant protein of human SLC9A3R1
Isotype IgG
Purification Affinity purification
Target
Alternative Name SLC9A3R1 (SLC9A3R1 Antibody Abstract)
Background

Synonyms: EBP 50,EBP50,Ezrin radixin moesin binding phosphoprotein 50,Ezrin-radixin-moesin-binding phosphoprotein 50,Na(+)/H(+) exchange regulatory cofactor NHE RF,Na(+)/H(+) exchange regulatory cofactor NHE-RF1,Na+/H+ exchange regulatory co factor,NHERF 1,NHERF,NHERF-1,NHERF1,NHRF1,NPHLOP2,Regulatory cofactor of Na(+)/H(+) exchanger,Slc9a3r1,Sodium hydrogen exchanger regulatory factor 1,Sodium-hydrogen exchanger regulatory factor 1,Sodium/hydrogen exchanger regulatory factor 1,Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1,Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1,Solute carrier family 9 isoform 3 regulatory factor 1,Solute carrier family 9 isoform A3 regulatory factor 1,Solute carrier family 9 member 3 regulator 1

Background: This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.

Molecular Weight

Observed_MW: 50kDa

Calculated_MW: 22kDa/38kDa

Gene ID 9368
UniProt O14745
Pathways Proton Transport, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, SARS-CoV-2 Protein Interactome
Application Notes WB 1:1000 - 1:4000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Images
Image no. 1 for anti-Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3), Member 3 Regulator 1 (SLC9A3R1) antibody (ABIN5968198) Western blot analysis of extracts of various cell lines, using SLC9A3R1 antibody.