ALKBH5 antibody (AA 245-394)

Catalog No. ABIN6136806

Product Details anti-ALKBH5 Antibody

Target: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Binding Specificity: AA 245-394

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLPVRRGSVT VLSGYAADEI THCIRPQDIK ERRAVIILRK TRLDAPRLET KSLSSSVLPP SYASDRLSGN NRDPALKPKR SHRKADPDAA HRPRILEMDK EENRRSVLLP THRRRGSFSS ENYWRKSYES SEDCSEAAGS PARKVKMRRH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 245-394 of human ALKBH5 (NP_060228.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ALKBH5

Target: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Alternative Name: ALKBH5 (ALKBH5 Products)

Background: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6-methyladenosine (m6A RNA, the most prevalent internal modification of messenger RNA (mRNA in higher eukaryotes. Can also demethylate N(6-methyladenosine in single-stranded DNA (in vitro. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity.,ALKBH5,ABH5,OFOXD,OFOXD1,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RNA Binding,ALKBH5

Molecular Weight: 43 kDa/44 kDa/52 kDa

Gene ID: 54890

UniProt: Q6P6C2