BMPR2 antibody (AA 27-150)

Catalog No. ABIN6137608

Product Details anti-BMPR2 Antibody

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Binding Specificity: AA 27-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: SQNQERLCAF KDPYQQDLGI GESRISHENG TILCSKGSTC YGLWEKSKGD INLVKQGCWS HIGDPQECHY EECVVTTTPP SIQNGTYRFC CCSTDLCNVN FTENFPPPDT TPLSPPHSFN RDET

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-150 of human BMPR2 (NP_001195.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-BMPR2 antibody (ABIN6137608)

Shi, Zhu, Wei, Fu, Wang, Liu, Zhang, Liang, Xing, Wang, Wang: "Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition." in: Life sciences, Vol. 207, pp. 442-450, (2018) (PubMed).

Target Details for BMPR2

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Alternative Name: BMPR2 (BMPR2 Products)

Background: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.,BMPR2,BMPR-II,BMPR3,BMR2,BRK-3,POVD1,PPH1,T-ALK,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Bone,Growth factor,Stem Cells,Mesenchymal Stem Cells,Cardiovascular,Heart,Hypertrophy,Receptors,BMPR2

Molecular Weight: 59 kDa/115 kDa

Gene ID: 659

UniProt: Q13873

Pathways: Growth Factor Binding