STRA13 antibody (AA 1-63)

Catalog No. ABIN6148631

Product Details anti-STRA13 Antibody

Target: STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))

Binding Specificity: AA 1-63

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRA13 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MEGAGAGSGF RKELVSRLLH LHFKDDKTKE AAVRGVRQAQ AEDALRVDVD QLEKVLPQLL LDF

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human STRA13 (NP_659435.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for STRA13

Target: STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))

Alternative Name: STRA13 (STRA13 Products)

Background: DNA-binding component of the Fanconi anemia (FA core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer, crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins, rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer, involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.,CENPX,CENP-X,D9,FAAP10,MHF2,STRA13,Epigenetics & Nuclear Signaling,DNA Damage & Repair,STRA13

Molecular Weight: 6 kDa/7 kDa/8 kDa

Gene ID: 201254

UniProt: A8MT69