Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

STRA13 antibody

STRA13 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7264936
  • Target See all STRA13 Antibodies
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Reactivity
    Human
    Host
    • 6
    Rabbit
    Clonality
    • 6
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    • 1
    This STRA13 antibody is un-conjugated
    Application
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human STRA13 (NP_659435.2).
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Alternative Name
    STRA13 (STRA13 Products)
    Synonyms
    CENP-X antibody, CENPX antibody, D9 antibody, FAAP10 antibody, MHF2 antibody, BHLHB2 antibody, centromere protein X antibody, CENPX antibody, Cenpx antibody
    Background
    DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
    Molecular Weight

    Observed_MW: 14 kDa

    Calculated_MW: 6 kDa/7 kDa/8 kDa

    Gene ID
    201254
    UniProt
    A8MT69
You are here:
Support