Prostaglandin D2 Receptor 2 (PTGDR2) (AA 329-348) antibody

Catalog No. ABIN615787

Product Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Binding Specificity: AA 329-348

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: 329-348 [DDSELGGAGS SRRRRTSSTA ]

Specificity: This antibody reacts to G Protein-Coupled Receptor GPR44 (CRTH2) near the C-terminus.

Purification: Immunoaffinity Chromatography

Immunogen: GPR44 antibody was raised against synthetic peptide- KLH conjugated Genename: GPR44

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Alternative Name: CD294 / GPR44 (PTGDR2 Products)

Background: GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.Synonyms: CRTH2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, DL1R, Putative G-protein coupled receptor 44

Gene ID: 11251

NCBI Accession: NP_004769

UniProt: Q9Y5Y4

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling