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Prostaglandin D2 Receptor 2 Products

(Prostaglandin D2 Receptor 2 (PTGDR2))

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This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011].

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Featured Prostaglandin D2 Receptor 2 Categories

Prostaglandin D2 Receptor 2 Antibodies

High quality antibodies with extensive validation data.

Recommended Prostaglandin D2 Receptor 2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application EIA, IHC (p), WB
Validations
  • (4)
Cat. No. ABIN615056
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse, Rat
Application FACS, IF, IHC, WB
Validations
  • (4)
Cat. No. ABIN7043564
Quantity 25 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN3187908
Quantity 100 μL
Datasheet Datasheet

Recommended Prostaglandin D2 Receptor 2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3120396
Quantity 0.25 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094478
Quantity 0.5 mg
Datasheet Datasheet

Latest Publications for our Prostaglandin D2 Receptor 2 products

Guan, Svennersten, de Verdier, Wiklund, Gustafsson: "Prostaglandin D2 effects and DP1 /DP2 receptor distribution in guinea pig urinary bladder out-flow region." in: Journal of cellular and molecular medicine, (2016) (PubMed).

Huang, Hazen, Shang, Zhou, Wu, Yan, Lin, Solon, Luis, Ngu, Shi, Katewa, Choy, Ramamoorthi, Castellanos, Balazs, Xu, Lee, Matsumoto, Payandeh, Arron, Hongo, Wang, Hötzel, Austin, Reif: "Depletion of major pathogenic cells in asthma by targeting CRTh2." in: JCI insight, Vol. 1, Issue 7, pp. e86689, (2016) (PubMed).

Guan, Svennersten, de Verdier, Wiklund, Gustafsson: "Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2." in: British journal of pharmacology, Vol. 172, Issue 16, pp. 4024-37, (2015) (PubMed).

Chimen, McGettrick, Apta, Kuravi, Yates, Kennedy, Odedra, Alassiri, Harrison, Martin, Barone, Nayar, Hitchcock, Cunningham, Raza, Filer, Copland, Dick, Robinson, Kalia, Walker, Buckley, Nash et al.: "Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. ..." in: Nature medicine, Vol. 21, Issue 5, pp. 467-75, (2015) (PubMed).

Zhang, Grabauskas, Wu, Joo, Heldsinger, Song, Owyang, Yu: "Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 304, Issue 10, pp. G908-16, (2013) (PubMed).

El-Shazly, Begon, Kustermans, Arafa, Dortu, Henket, Lefebvre, Louis, Delvenne: "Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways." in: The Journal of biological chemistry, Vol. 288, Issue 2, pp. 1374-84, (2013) (PubMed).

Gao, Wang, Qiu, Zhou, Shi, Zhang, Fan: "Tumor stroma reaction-related gene signature predicts clinical outcome in human hepatocellular carcinoma." in: Cancer science, Vol. 102, Issue 8, pp. 1522-31, (2011) (PubMed).

Guo, Baglole, OLoughlin, Feldon, Phipps: "Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 15794-804, (2010) (PubMed).

Chevalier, Stock, Fisher, Dupont, Fric, Fargeau, Leport, Soler, Fabien, Pruniaux, Fink, Bertrand, McNeish, Li: "Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 4, pp. 2056-60, (2005) (PubMed).

Shichijo, Sugimoto, Nagao, Inbe, Encinas, Takeshita, Bacon, Gantner et al.: "Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced ..." in: The Journal of pharmacology and experimental therapeutics, Vol. 307, Issue 2, pp. 518-25, (2003) (PubMed).

Synonyms and alternative names related to Prostaglandin D2 Receptor 2

prostaglandin D2 receptor 2 (PTGDR2), prostaglandin D2 receptor 2 (Ptgdr2), CD294, CRTH2, Crth2, DL1R, DP2, GPR44, Gpr44, Grp45, Ptgdr2

Protein level used designations for Prostaglandin D2 Receptor 2

  • G protein-coupled receptor 44
  • G-protein coupled receptor 44
  • chemoattractant receptor homologous molecule expressed on T helper type 2 cells
  • chemoattractant receptor-homologous molecule expressed on TH2 cells
  • putative G-protein coupled receptor 44
  • PGD2 receptor
  • prostaglandin D2 receptor 2
  • prostaglandin D2 receptor CRTH2
  • G-protein coupled receptor
  • chemoattractant receptor-homologous molecule expressed on Th2 cells
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