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DcR2 antibody (AA 1-210) (APC)

Name: DcR2 antibody (AA 1-210) (APC)
Brand: antibodies-online
SKU: ABIN6240814
Price: 539.19 USD
Availability: InStock

TNFRSF10D Reactivity: Human FACS Host: Mouse Monoclonal TRAIL-R4-01 APC

Flow cytometry surface staining pattern of CD264 transfected HEK-293 cells using anti-human CD264 (TRAIL-R4-01) APC (concentration in sample 1,67 μg/mL). (DcR2 antibody (AA 1-210) (APC))

FACS

Separation of cells stained using anti-human CD264 (TRAIL-R4-01) APC antibody (concentration in sample 1,67 μg/mL, red-filled) from CD264 cells stained using mouse IgG1 isotype control (MOPC-21) APC antibody (concentration in sample 1,67 μg/mL, black-dashed) in flow cytometry analysis (surface staining) of CD264 transfected HEK-293 cell suspension. (DcR2 antibody (AA 1-210) (APC))

FACS

2 images

Catalog No. ABIN6240814

Datasheet as PDF

Target See all DcR2 (TNFRSF10D) Antibodies

DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
Binding Specificity
5

5

4

4

4

4

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1
AA 1-210
Reactivity
72

5

4
Human
Host
57

15
Mouse
Compatible Secondaries
Clonality
56

16
Monoclonal
Conjugate
34

6

5

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This DcR2 antibody is conjugated to APC
Application
49

29

17

11

5

5

3

3

2

1

1
Flow Cytometry (FACS)

Specificity

The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Cross-Reactivity (Details)

Human

Purification

Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen

TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

Clone

TRAIL-R4-01

Isotype

IgG1

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anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 1-210) antibody (PE)
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 249-263) antibody
TNFRSF10D Reactivity: Human, Mouse, Rat WB, IHC, ICC Host: Rabbit Polyclonal unconjugated

anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 257-386) antibody
TNFRSF10D Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated

anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 249-263), (Intracellular) antibody
TNFRSF10D Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated

anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) antibody
TNFRSF10D Reactivity: Human WB, IP Host: Mouse Monoclonal B-P30 unconjugated

Application Notes

Flow cytometry: Recommended dilution: 1-5 μg/mL.

Comment

The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Restrictions

For Research Use only
Concentration

0.1 mg/mL

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Storage

4 °C

Storage Comment

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Target

DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Alternative Name

CD264 / TRAIL-R4 (TNFRSF10D Products)

Background

TNF receptor superfamily member 10d,TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).,TNFRSF10D, DcR2, TRUNDD, TRAILR4

Gene ID

8793

UniProt

Q9UBN6

Pathways

Apoptosis