Minichromosome Maintenance Complex Component 2 (MCM2) antibody

Details for Product No. ABIN6263158
Antigen
  • CG7538
  • DmMCM2
  • DmMcm2
  • DmeMCM2
  • Dmel\\CG7538
  • MCM2
  • MCM2-7
  • MCM2_DROME
  • McM2
  • PCR3
  • dMCM2
  • l(3)rL074
  • XMcm2
  • bm28
  • ccnl1
  • cdc19
  • cdcl1
  • mitotin
  • cb737
  • chunp6905
  • BM28
  • CCNL1
  • CDCL1
  • D3S3194
  • MITOTIN
  • MCM7
  • AA959861
  • AW476101
  • Mcmd2
  • mKIAA0030
  • Minichromosome maintenance 2
  • minichromosome maintenance complex component 2
  • minichromosome maintenance complex component 2 L homeolog
  • Mcm2
  • mcm2
  • MCM2
  • mcm2.L
Reactivity
Human, Mouse (Murine), Rat (Rattus)
214
104
63
11
11
10
9
7
5
3
3
2
2
1
1
Host
Rabbit
174
61
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
10
8
8
4
4
4
3
3
3
3
3
3
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
199
110
90
57
34
17
17
16
13
6
4
4
4
3
2
Options
Immunogen A synthesized peptide derived from human MCM2
Isotype IgG
Specificity MCM2 antibody detects endogenous levels of total MCM2
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Antigen
Alternative Name MCM2 (MCM2 Antibody Abstract)
Background

Description: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.

Gene: MCM2

Molecular Weight 120kDa
Gene ID 4171
UniProt P49736
Pathways DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
Application Notes WB: 1:500~1:3000 IHC: 1:50~1:200 IF/ICC: 1:100~1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Minichromosome Maintenance Complex Component 2 (MCM2) antibody (ABIN6263158) Western blot analysis on 293 cell lysate using MCM2 Antibody. The lane on the left is...
Image no. 2 for anti-Minichromosome Maintenance Complex Component 2 (MCM2) antibody (ABIN6263158) ABIN6266586 at 1/100 staining human colon carcinoma tissue sections by IHC-P. The tis...
Image no. 3 for anti-Minichromosome Maintenance Complex Component 2 (MCM2) antibody (ABIN6263158) Western blot analysis of extracts from rat spleen, using MCM2 Antibody.
Image no. 4 for anti-Minichromosome Maintenance Complex Component 2 (MCM2) antibody (ABIN6263158) ABIN6266586 staining HeLa cells by IF/ICC. The sample were fixed with PFA and permeab...
Did you look for something else?