ANO1 antibody (Anoctamin 1, Calcium Activated Chloride Channel)

Details for Product anti-ANO1 Antibody No. ABIN6297579
Antigen
  • DOG1
  • ORAOV2
  • TAOS2
  • TMEM16A
  • Tmem16a
  • anoctamin 1
  • anoctamin 1, calcium activated chloride channel
  • Ano1
  • ANO1
Reactivity
Human
352
46
35
5
2
2
2
2
1
Host
Mouse
220
136
Clonality
Monoclonal
Conjugate
This ANO1 antibody is un-conjugated
14
11
9
9
9
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
2
2
2
2
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
200
193
153
83
65
56
54
20
15
13
4
4
3
2
1
Options
Purpose Mouse anti-Human TMEM16A Antibody (DOG1) [Sodium Azide Free]
Immunogen Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.
Specificity Cell Surface and Cytoplasmic
Purification Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.
Plasmids, Primers & others Plasmids, Primers & others ANO1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Anoctamin-1 (ANO1 Antibody Abstract)
Background

Target Description: Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GIST 's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for TMEM16A has been reported in 97.8 percent of scorable GIST 's, including all c-kit negative GIST 's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST 's is nearly identical: 94.4 % vs. 94.7 %.

Gene Symbol: ANO1///DOG1///ORAOV2///TAOS2///TMEM16A

Gene ID 55107
UniProt Q5XXA6
Application Notes FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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