Tyrosinase  (TYR) antibody

Details for Product No. ABIN6297626
Antigen
  • sandy
  • zgc:109705
  • TYR
  • TYRO
  • tyr
  • LOC100136546
  • CMM8
  • OCA1A
  • OCAIA
  • SHEP3
  • albino
  • c
  • skc35
  • C
  • tyrosinase
  • TYRosinase
  • tyrosinase S homeolog
  • tyr
  • tyr-5
  • tyr.S
  • TYR
  • Celal_3121
  • Halhy_4121
  • Mesop_2736
  • LOC100136546
  • Tyr
Reactivity
Human
256
45
39
10
7
6
6
5
2
2
2
2
2
1
1
1
1
Host
Mouse
139
133
2
Clonality
Monoclonal
Conjugate
Un-conjugated
10
6
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
125
125
98
81
81
63
57
23
20
15
13
12
11
10
3
1
Options
Purpose Mouse anti-Human Tyrosinase Antibody [Sodium Azide Free]
Immunogen Recombinant tyrosinase protein was used as the immunogen for this Tyrosinase antibody.
Specificity Cytoplasmic
Purification Recombinant tyrosinase protein was used as the immunogen for this Tyrosinase antibody.
Antigen
Alternative Name Tyrosinase (TYR Antibody Abstract)
Background

Target Description: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas.

Gene Symbol: TYR

Gene ID 7299
UniProt P14679
Application Notes Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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