TYR antibody
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- Target See all TYR Antibodies
- TYR (Tyrosinase (TYR))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TYR antibody is un-conjugated
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Application
- Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)
- Purpose
- Mouse anti-Human Tyrosinase Antibody [Sodium Azide Free]
- Specificity
- Cytoplasmic
- Purification
- Recombinant tyrosinase protein was used as the immunogen for this Tyrosinase antibody.
- Immunogen
- Recombinant tyrosinase protein was used as the immunogen for this Tyrosinase antibody.
- Top Product
- Discover our top product TYR Primary Antibody
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- Application Notes
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) - Restrictions
- For Research Use only
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- Buffer
- In 1X PBS, BSA free, sodium azide free
- Preservative
- Azide free
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- TYR (Tyrosinase (TYR))
- Alternative Name
- Tyrosinase (TYR Products)
- Synonyms
- sandy antibody, zgc:109705 antibody, TYR antibody, TYRO antibody, tyr antibody, LOC100136546 antibody, CMM8 antibody, OCA1A antibody, OCAIA antibody, SHEP3 antibody, albino antibody, c antibody, skc35 antibody, C antibody, tyrosinase antibody, TYRosinase antibody, tyrosinase S homeolog antibody, tyr antibody, tyr-5 antibody, tyr.S antibody, TYR antibody, Celal_3121 antibody, Halhy_4121 antibody, Mesop_2736 antibody, LOC100136546 antibody, Tyr antibody
- Background
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Target Description: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas.
Gene Symbol: TYR
- Gene ID
- 7299
- UniProt
- P14679
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