CD25 antibody (Interleukin 2 Receptor, alpha)

Details for Product anti-IL2RA Antibody No. ABIN6297678
Antigen
  • CD25
  • IDDM10
  • IL2R
  • TCGFR
  • IL2RAC
  • IL-2RA
  • Il2r
  • Ly-43
  • interleukin 2 receptor subunit alpha
  • interleukin-2 receptor subunit alpha-like
  • interleukin 2 receptor, alpha chain
  • IL2RA
  • Il2ra
  • LOC100222957
Reactivity
Human
484
300
102
19
15
6
6
5
5
5
4
3
1
Host
Mouse
429
240
158
4
3
3
2
1
Clonality
Monoclonal
Conjugate
This CD25 antibody is un-conjugated
110
105
80
64
16
12
11
10
9
9
7
7
5
5
5
5
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Functional Studies (Func), Immunofluorescence (IF)
629
146
126
118
100
97
50
39
27
20
17
14
13
12
8
5
2
2
2
2
1
1
1
1
1
1
1
1
1
Options
Purpose Mouse anti-Human CD25 Antibody [Sodium Azide Free]
Immunogen Stimulated human leukocytes were used as the immunogen for the CD25 antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for the CD25 antibody.
Plasmids, Primers & others Plasmids, Primers & others CD25 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Interleukin-2 receptor subunit alpha (IL2RA Antibody Abstract)
Background

Target Description: Recognizes a protein of 55 kDa, identified as CD25 (Workshop IV, Code A27). CD25 is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkins disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 Molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R b-chain, p75) and CD132 (common g-chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This mAb recognizes the epitope B, which is located at residue 3-104 of CD25 and can effectively block IL-2 binding to CD25.

Gene Symbol: IL2RA

Gene ID 3559
UniProt P01589
Pathways JAK-STAT Signaling, Growth Factor Binding, Activated T Cell Proliferation
Application Notes Functional Activity (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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