CD43 antibody (Sialophorin)

Details for Product anti-SPN Antibody No. ABIN6297681
Target
Reactivity
Human
233
15
13
2
1
Host
Mouse
124
122
10
Clonality
Monoclonal
Conjugate
This CD43 antibody is un-conjugated
22
17
17
12
10
9
4
4
4
4
4
4
4
4
4
4
4
4
4
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
145
139
99
90
71
47
31
24
15
7
7
5
3
2
1
Options
Purpose Mouse anti-Human CD43 Antibody [IHC only]
Immunogen Stimulated human leukocytes were used as the immunogen for the CD43 antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for the CD43 antibody.
Target
Alternative Name Leukosialin (SPN Antibody Abstract)
Background

Target Description: It recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43 (Workshop III). 70-90 % of T-cell lymphomas and from 22-37 % of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.

Gene Symbol: SPN///CD43
Gene ID 6693
UniProt P16150
Pathways Regulation of Leukocyte Mediated Immunity
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.