CD74 antibody
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- Target See all CD74 Antibodies
- CD74 (HLA-DR-gamma (CD74))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD74 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Purpose
- Mouse anti-Human CD74 Antibody Cocktail [IHC only]
- Specificity
- Cell surface and paranuclear globular
- Purification
- SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.
- Immunogen
- SU-DHL-4 lymphoma cells (LN-2) and recombinant full-length human protein (CLIP/813) were used as the immunogen for the CD74 antibody cocktail.
- Top Product
- Discover our top product CD74 Primary Antibody
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- Application Notes
- Prediluted format : incubate for 30 min at RT (2)
- Restrictions
- For Research Use only
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- Buffer
- Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- CD74 (HLA-DR-gamma (CD74))
- Alternative Name
- HLA class II histocompatibility antigen gamma chain (CD74 Products)
- Synonyms
- DHLAG antibody, HLADG antibody, II antibody, Ia-GAMMA antibody, CLIP antibody, Ii antibody, INVG34 antibody, Iclp-1 antibody, iclp1 antibody, wu:fb11f09 antibody, wu:fb12a01 antibody, wu:fb13d06 antibody, wu:fk94e07 antibody, Iclp-2 antibody, cd74 antibody, iclp2 antibody, zgc:123161 antibody, CD74 molecule antibody, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody, CD74 molecule, major histocompatibility complex, class II invariant chain a antibody, CD74 molecule, major histocompatibility complex, class II invariant chain b antibody, CD74 antibody, Cd74 antibody, cd74a antibody, cd74b antibody
- Background
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Target Description: It recognizes a protein of ~35 kDa, identified as CD74/CLIP. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Gene Symbol: CD74///DHLAG
- Gene ID
- 296
- UniProt
- P04233
- Pathways
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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